ELEVATED INFLAMMATORY RESPONSES AND TARGETED THERAPEUTIC INTERVENTION IN A PRECLINICAL MOUSE MODEL OF ATAXIA-TELANGIECTASIA LUNG DISEASE

Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease

Abstract Ataxia-telangiectasia (A-T) is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects.A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the lung complications are poorly understood, and there are currentl

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Integrated Hydrodynamic Modeling of Dam Failure and Downstream Flood Inundation near Kathmandu, Nepal using MIKE Hydro River Model

The integrated hydrodynamic modeling study conducted in the Kathmandu valley, Nepal, utilizing the MIKE Hydro River Model and incorporating diverse datasets, including satellite imageries, ALOS PALSAR RTC DEM data, topographical map at 1:25,000 scale and hydraulic data.Various scenarios, including a probable maximum flood (PMF) routing simulation,

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The Information Literacy of Survey Mark Hunting: A Dialogue

In Brief: This article makes connections between the ACRL Framework for Information Literacy for Higher Education and the activity of survey mark hunting.After a brief review of the literature related to geographic information systems (GIS), information literacy, and gamification of learning, the authors enter into CS-514 a dialogue in which they d

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